Hyperbaric Oxygen Therapy
About
mild Hyperbaric Oxygen Therapy (mHBOT) uses a pressurized chamber to allow the cells of the body to become readily saturated with oxygen which becomes more bioavailable in facilitating the body's natural healing capacity.
Benefits
Hyperoxygenation
HBOT increases oxygen carried into the blood stream. This allows oxygen to dissolve deep into the body and reverse hypoxia. This can help areas damaged during surgery or due to blood loss.
Anti-inflammation
HBOT downregulates inflammatory pathways and constricts blood vessels. In the long term it also can turn off the genes responsible for inflammation.
Antimicrobial Effect
HBOT weakens infection-causing bacteria and strengthens the natural antioxidants and free radical scavengers that are present in your body.
Neovascularization
HBOT stimulates the growth of new blood vessels, there by increasing circulation and revitalizing the tissue.
Stem Cell Mobilization
During HBOT, the circulation of stem cells can increase eight fold. Stem cells are key in the regeneration and healing process.
Mitochondrial Support
HBOT facilitates the production of adenosine triphosphate or ATP. When damage occurs in the body the production of ATP is often interrupted. HBOT optimizes the energy production of your cells.
Research
Mechanisms
--Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127 Suppl 1(Suppl 1):131S–141S. doi:10.1097/PRS.0b013e3181fbe2bf
--Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008
--A.L. Gill, C.N.A. Bell, Hyperbaric oxygen: its uses, mechanisms of action and outcomes, QJM: An International Journal of Medicine, Volume 97, Issue 7, July 2004, Pages 385–395, https://doi.org/10.1093/qjmed/hch074
--Hink J, Jansen E. Are superoxide and/or hydrogen peroxide responsible for some of the beneficial effects of hyperbaric oxygen therapy? Med. Hypotheses, 57 (6) (2001), pp. 764-769.
Applications
Fife CE, Eckert KA, Carter MJ. An update on the appropriate role for hyperbaric oxygen: indications and evidence. Plast Reconstr Surg. 2016;138(3 Suppl):107S–16S. doi:10.1097/PRS.0000000000002714
Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol (1985). 2009;106(3):988–995. doi:10.1152/japplphysiol.91004.2008
Fujita N, Ono M, Tomioka T, et al. Effects of hyperbaric oxygen at 1.25 atmospheres absolute with normal air on macrophage number and infiltration during rat skeletal muscle regeneration. PLoS One. 2014;9(12):e115685. Published 2014 Dec 22. doi:10.1371/journal.pone.0115685
Vadas D, Kalichman L, Hadanny A, et al. Hyperbaric oxygen environment can enhance brain activity and multitasking performance. Front Integr Neurosci. 2017;11:25. Published 2017 Sep 27. doi:10.3389/fnint.2017.00025
Traumatic Brain Injury:
Clinical Study: Mild Hyperbarics for Impaired Brain Function by Dr. Gunnar Heuser, MD, PhD, FACP
"Every one of the patients who participated in the study showed improvement after only 10 treatments. Reporting fewer problems with short term memory, balance, headaches, and other symptoms of poor circulation in the brain. The SPECT scans objectively confirmed an increase in blood flow and oxygen to effected areas of the brain"https://www.drneubrander.com/Files/Brain%20Study-clinicalstudyimpaired%20brain%20function.pdf?fbclid=IwAR0XmFONAedho_8_68l_UT6inlpIeonobzXWi3hr7YbFLpymU91sf0TDEEc
Boussi-Gross R, Golan H, Fishlev G, et al. Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury – randomized prospective trial. PLoS One. 2013;8(11):e79995. Published 2013 Nov 15. doi:10.1371/journal.pone.0079995
Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508
Meng XE, Zhang Y, Li N, et al. Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of tlr4/nf-κb signaling pathway. Med Sci Monit. 2016;22:284–288. Published 2016 Jan 26. doi:10.12659/msm.894148
Vlodavsky, E. Palzur, M. Feinsod, et al. Evaluation of the apoptosis-related proteins of the BCL-2 family in the traumatic penumbra area of the rat model of cerebral contusion, treated by hyperbaric oxygen therapy: a quantitative immunohistochemical study. Acta Neuropathol., 110 (2) (2005), pp. 120-126
Hadanny A, Abbott S, Suzin G, et al. Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis. BMJ Open. 2018;8(9):e023387. Published 2018 Sep 28. doi:10.1136/bmjopen-2018-023387
Dong Y, Hu XH, Wu T, et al. Effect of hyperbaric oxygenation therapy on post-concussion syndrome [published correction appears in Exp Ther Med. 2018 Dec;16(6):4918]. Exp Ther Med. 2018;16(3):2193–2202. doi:10.3892/etm.2018.6463
Tal S, Hadanny A, Sasson E, et al. Hyperbaric oxygen therapy can induce angiogenesis and regeneration of nerve fibers in traumatic brain injury patients. Front Hum Neurosci. 2017;11:508. Published 2017 Oct 19. doi:10.3389/fnhum.2017.00508
Tsutsumi I, Tsujimoto Y, Takahashi S, et al. Hyperbaric oxygen therapy for persistent post‐concussion syndrome following mild traumatic brain injury. Cochrane Database Syst Rev. 2017;2017(7):CD012727. Published 2017 Jul 16. doi:10.1002/14651858.CD012727
Eve DJ, Steele MR, Sanberg PR, et al. Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury. Neuropsychiatr Dis Treat. 2016;12:2689–2705. Published 2016 Oct 20. doi:10.2147/NDT.S110126
Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial. https://www.nature.com/articles/s41598-022-19395-y
Stem Cells:
Thom SR, Bhopale VM, Velazquez OC, et al. Stem cell mobilization by hyperbaric oxygen. American Journal of Physiology-Heart and Circulatory Physiology 2006 290:4, H1378-H1386
Oyaizu T, Enomoto M, Yamamoto N, et al. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018;8(1):1288. Published 2018 Jan 22. doi:10.1038/s41598-018-19670-x
Liska GM, Lippert T, Russo E, et al. A dual role for hyperbaric oxygen in stroke neuroprotection: preconditioning of the brain and stem cells. Cond Med. 2018;1(4):151–166.
Peña-Villalobos I, Casanova-Maldonado I, Lois P, et al. Hyperbaric oxygen increases stem cell proliferation, angiogenesis and wound-healing ability of WJ-MSCs in diabetic mice. Front Physiol. 2018;9:995. Published 2018 Jul 30. doi:10.3389/fphys.2018.00995
Fosen KM, Thom SR. Hyperbaric oxygen, vasculogenic stem cells, and wound healing. Antioxid Redox Signal. 2014;21(11):1634–1647. doi:10.1089/ars.2014.5940
Milovanova TN, Bhopale VM, Sorokina EM, et al. Hyperbaric oxygen stimulates vasculogenic stem cell growth and differentiation in vivo. J Appl Physiol (1985). 2009;106(2):711–728. doi:10.1152/japplphysiol.91054.2008
MacLaughlin KJ, Barton GP, Braun RK, Eldridge MW. Effect of intermittent hyperoxia on stem cell mobilization and cytokine expression. Med Gas Res. 2019;9(3):139–144. doi:10.4103/2045-9912.266989
Mitochondrial Health:
Palzur E, Zaaroor M, Vlodavsky E, et al. Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain Res., 1221 (2008), pp. 126-133
K.R. Dave, R. Prado, R. Busto, A.P. Raval, W.G. Bradley, D. Torbati, M.A. Pérez-pinzón,
Hyperbaric oxygen therapy protects against mitochondrial dysfunction and delays onset of motor neuron disease in wobbler mice, Neuroscience, Volume 120, Issue 1, 2003, Pages 113-120,
ISSN 0306-4522, https://doi.org/10.1016/S0306-4522(03)00244-6.
Meyer JN, Hartman JH, Mello DF. Mitochondrial toxicity. Toxicological Sciences, Volume 162, Issue 1, March 2018, Pages 15–23
Meyer JN, Leung MC, Rooney JP, et al. Mitochondria as a target of environmental toxicants. Toxicol Sci. 2013;134(1):1–17. doi:10.1093/toxsci/kft102
