Far-Field Infrared Therapy

About
Developments in far-field infrared therapy are showing significant improvements in neuroinflammatory conditions including wound and burn healing, injury recovery, Parkinson's Disease, and Alzheimer's Disease with more evidence accumulating regarding it's broad therapeutic applications.

Gladiator Therapeutics products provide this technology in a unique way that requires no external devices or powering making it accessible, portable, and easy to apply in support of other therapeutic approaches in your treatment plan. As a scholar of the Carrick Institute for Graduate Studies in clinical neuroscience, Dr. Wingate has early access to this technology available only to approved medical practitioners. For more information on this service please watch the below informational video from Professor Frederick Carrick:  








 

 

 

 

Research

Mechanisms

Recent studies suggest Far-field infrared [FIR] induces nitric oxide, a key molecule with an established role in central nervous system function and in so-doing:
-Reduces harmful oxidative stress [1]
-Demonstrates anti-inflammatory effects [1]
-Shown to reverse progressive degeneration of of neurons in the substantia nigra and dopaminergic pathways in Parkinson's Disease [2].
-Induces heat shock proteins (HSPs) [3] that participate in the degradation of misfolded and aggregated proteins[4]
        -can also protect against neurodegeneration caused by protein aggregation [5].

-Mitochondrial biogenesis
-Increased glucose metabolism and mitochondrial function
-"also probably improve mitochondrial oxidative respiration in skeletal muscle and invigorate mitophagy [6], which may contribute to the increased motor performance."
-Microtubule facilitation of cell migration sustaining coordinated cell movements [7,8],.

-"Rhythmic oscillation patterns facilitate the cellular microtubular generation of electric and mechanical patterns that impact biomolecular recognition, which boosts our inherent ability for self-healing [9]

The Biological Effectiveness and Medical Significance of Far Infrared Radiation (FIR)
"FIR radiations improve the microcirculation of the human body, stimulate cell growth, penetrate through skin tissues non-invasively, create intramolecular vibrations create an overall healthy metabolism, which ultimately affects overall improved cardiac and metabolic activity...
In this review, we explored the biological effectiveness and the medical significance of Far infrared radiation (FIR) in murine melanoma Cell Growth, Lymphedema, airborne viruses, Cardiac diseases, Wound healing and burns, Autonomic Activities, Hemodialysis, Allergic Rhinitis, Aesthetic medicine, textiles, and other domains such as obesity and gut microbiota.
https://doi.org/10.18034/mjmbr.v8i1.564















Applications

Wound Healing

Accelerated Wound Healing Using a Novel Far-Infrared Ceramic Blanket - Wound healing has been demonstrated to be significantly improved in a mouse model exposed to cFIRB. The ceramic blanket also promotes the survival, proliferation, and wound healing of [mesenchymal stem cells]
https://www.mdpi.com/2075-1729/11/9/878

COLLEGE OF MEDICINE UNIV. OF CENTRAL FLORIDA RESEARCH WOUNDS HEAL FASTER WITH NEW TREATMENT: MILITARY MEDICINE DISCOVERY - findings were accepted for presentation at the Military Health System Research Symposium (MHSRS), scheduled in Kissimmee, Florida, Aug 23-26, 2021. The MHSRS is the USA Department of Defense’s premier scientific meeting that focuses specifically on the unique medical needs of the Warfighter. 
https://gladiatortherapeutics.com/news-press-release/college-of-medicine-univ-of-central-florida-research-wounds-heal-faster-with-new-


Motor Function (Parkinson's Disease Model)

Amelioration of Motor Performance and Nigrostriatal Dopamine Cell Volume Using a Novel Far-Infrared Ceramic Blanket in an A53T Alpha-Synuclein Transgenic Parkinson’s Disease Mouse Model - "There was a significant statistical and substantive increase in the cellular composition of the Striatum and substantia nigra of cFIR-treated mice. Improvement in motor performance is seen in PD mice and wild mice and is associated with increases in cell volume in the substantia nigra and striatum after treatment."
https://www.mdpi.com/1467-3045/45/12/613

Sources:
 

1. Carrick, F.R.; Hernandez, L.S.A.V.; Sugaya, K. Amelioration of Motor Performance and Nigrostriatal Dopamine Cell Volume Using a Novel Far-Infrared Ceramic Blanket in an A53T Alpha-Synuclein Transgenic Parkinson’s Disease Mouse Model. Curr. Issues Mol. Biol. 2023, 45, 9823-9837. https://doi.org/10.3390/cimb45120613

2. Wang, L.; Dan, Q.; Xu, B.; Chen, Y.; Zheng, T. Research progress on gas signal molecular therapy for Parkinson’s disease. Open Life Sci. 2023, 18, 20220658. [Google Scholar] [CrossRef] [PubMed]

3. Kimura, I.; Yamamoto, T.; Nakamura, K.; Uenishi, T.; Asai, T.; Kita, M.; Kanamura, N. Effects of far infrared radiation by isotropic high-density carbon on the human oral mucosa. Arch. Oral Biol. 2018, 94, 62–68. [Google Scholar] [CrossRef]

4. Zhao, Z.; Li, Z.; Du, F.; Wang, Y.; Wu, Y.; Lim, K.L.; Li, L.; Yang, N.; Yu, C.; Zhang, C. Linking Heat Shock Protein 70 and Parkin in Parkinson’s Disease. Mol. Neurobiol. 2023, 60, 7044–7059. [Google Scholar] [CrossRef] [PubMed]

5. Vendredy, L.; Adriaenssens, E.; Timmerman, V. Small heat shock proteins in neurodegenerative diseases. Cell Stress Chaperones 2020, 25, 679–699.

6. Lee, D.; Kim, Y.W.; Kim, J.H.; Yang, M.; Bae, H.; Lim, I.; Bang, H.; Go, K.C.; Yang, G.W.; Rho, Y.H.; et al. Improvement Characteristics of Bio-active Materials Coated Fabric on Rat Muscular Mitochondria. Korean J. Physiol. Pharmacol. 2015, 19, 283–289. [Google Scholar] [CrossRef]

7. Watanabe, T.; Noritake, J.; Kaibuchi, K. Regulation of microtubules in cell migration. Trends Cell Biol. 2005, 15, 76–83. [Google Scholar] [CrossRef]

8. Kodama, A.; Karakesisoglou, I.; Wong, E.; Vaezi, A.; Fuchs, E. ACF7: An essential integrator of microtubule dynamics. Cell 2003, 115, 343–354. [Google Scholar] [CrossRef]

9. Facchin, F.; Canaider, S.; Tassinari, R.; Zannini, C.; Bianconi, E.; Taglioli, V.; Olivi, E.; Cavallini, C.; Tausel, M.; Ventura, C. Physical energies to the rescue of damaged tissues. World J. Stem Cells 2019, 11, 297. [Google Scholar] [CrossRef]